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apalutamide will lessen the level or impact of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with drugs which are CYP3A4 substrates can lead to lower exposure to those medicines.modafinil will improve the stage or outcome of rabepraz
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